Niiho Y, Yamazaki T, Hosono T, Nakajima Y, Ishizaki M, Kurashige T
Tukuba Research Institute, Ohta's Isan Co. Ltd., Ibaraki, Japan.
Yakugaku Zasshi. 1993 Apr;113(4):334-42. doi: 10.1248/yakushi1947.113.4_334.
The present research was an attempt to determine the pharmacological actions as for anti-fatigue, anti-obesity and hypoglycemia of small peptide isolated from soybean in mice. Small peptide administration prevented the decrease in sporting movement induced by concussion stress for 3 h in mice. In addition, it should be noted that the recovery rate of fatigue in 60 min after small peptide administration was over one hundred percentage in comparison with that after pretreatment, while the equivalent dose administration of amino acid mixture with the same small peptide amino acid composition did not prevent the decrease in sporting movement. In gold-thioglucose (500 mg/kg (i.p.))-induced obese mouse body weight gain, liver weight and body lipid level around uterine were significantly reduced by the chronic oral administration of small peptide (200, 1000 mg/kg). Administration in 1000 mg per kg of small peptide significantly lowered hyperglycemia in 30 and 120 min after glucose (3 g/kg (p.o.)) administration, whereas the equivalent amino acid mixture showed no effect. In conclusion, it suggested that small peptide isolated from soybean might have some pharmacological effects of anti-fatigue, anti-obesity, and hypoglycemia.
本研究旨在确定从小豆中分离出的小肽对小鼠的抗疲劳、抗肥胖和降血糖药理作用。给予小肽可防止小鼠因震荡应激导致的运动减少持续3小时。此外，值得注意的是，与预处理后相比，给予小肽后60分钟内疲劳恢复率超过100%，而给予具有相同小肽氨基酸组成的氨基酸混合物等效剂量则不能防止运动减少。在金硫葡萄糖（500mg/kg（腹腔注射））诱导的肥胖小鼠中，长期口服小肽（200、1000mg/kg）可显著降低体重增加、肝脏重量和子宫周围的体脂水平。每千克给予1000mg小肽可显著降低葡萄糖（3g/kg（口服））给药后30分钟和120分钟的高血糖，而等效的氨基酸混合物则无此作用。总之，提示从小豆中分离出的小肽可能具有抗疲劳、抗肥胖和降血糖的药理作用。
