[Study on anti-alcohol mechanism of soybean peptide].

OBJECTIVE

To study the anti-alcohol mechanism of soybean peptide.

METHODS

The effect of soybean peptide on sleep latency (disappear of righting reflex)and sleep time on drunkenness (Polysomnography)mice induced by alcohol was observed. The concentration of ethanol in serum was measured by GC, and the content of GSH, MDA and ADH in liver homogenate were also determined.

RESULTS

The latency was increased significantly and the drunken sleep time was reduced significantly in drunkenness experiment(Polysomnography) models of alcohol with high-dose group of soybean peptide. Besides,the concentration of ethanol in serum was reduced significantly. At the same time, the content of GSH and ADH in liver were increased markedly, but the content of MDA increasing was inhibited on high-dose group mice of soybean peptide.

CONCLUSION

The soybean peptide can markedly dispel the effect of alcohol,which may be attributable to the antioxidation such as increasing the content of GSH and ADH in liver as well as inhibiting the content increasing of MDA.