Zhou Yong, Chen Ye, Wang Quan, Cai Meng-ting, Guo Xiao-lei
Zhong Yao Cai. 2014 Jun;37(6):1033-6.
To study the anti-alcohol mechanism of soybean peptide.
The effect of soybean peptide on sleep latency (disappear of righting reflex)and sleep time on drunkenness (Polysomnography)mice induced by alcohol was observed. The concentration of ethanol in serum was measured by GC, and the content of GSH, MDA and ADH in liver homogenate were also determined.
The latency was increased significantly and the drunken sleep time was reduced significantly in drunkenness experiment(Polysomnography) models of alcohol with high-dose group of soybean peptide. Besides,the concentration of ethanol in serum was reduced significantly. At the same time, the content of GSH and ADH in liver were increased markedly, but the content of MDA increasing was inhibited on high-dose group mice of soybean peptide.
The soybean peptide can markedly dispel the effect of alcohol,which may be attributable to the antioxidation such as increasing the content of GSH and ADH in liver as well as inhibiting the content increasing of MDA.
研究大豆肽的解酒机制。
观察大豆肽对酒精诱导的醉酒小鼠睡眠潜伏期（翻正反射消失）和睡眠时间（多导睡眠图）的影响。采用气相色谱法测定血清乙醇浓度，同时测定肝匀浆中谷胱甘肽（GSH）、丙二醛（MDA）和乙醇脱氢酶（ADH）的含量。
在大豆肽高剂量组酒精性醉酒实验（多导睡眠图）模型中，睡眠潜伏期显著延长，醉酒睡眠时间显著缩短。此外，血清乙醇浓度显著降低。同时，大豆肽高剂量组小鼠肝脏中GSH和ADH含量明显增加，而MDA含量增加受到抑制。
大豆肽能显著消除酒精的作用，这可能归因于其抗氧化作用，如增加肝脏中GSH和ADH的含量以及抑制MDA含量的增加。
