Ball R H, Filly R A, Goldstein R B, Callen P W
Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco.
J Ultrasound Med. 1993 Mar;12(3):131-4. doi: 10.7863/jum.1993.12.3.131.
The association of the "lemon sign" with myelomeningocele has been well documented. This study was performed to determine if this sign is exclusive to myelomeningocele. The study population included all abnormal fetuses in our data base with this sonographically observed finding, from 1988 to 1991 (total of 23 cases). Twelve fetuses were found to have a myelomeningocele and six an encephalocele. Five fetuses with the lemon sign demonstrated a variety of structural anomalies not involving the neural tube. This sonographic finding appears not to be limited to cases of myelomeningocele.
“柠檬征”与脊髓脊膜膨出的关联已有充分记录。本研究旨在确定该征象是否为脊髓脊膜膨出所特有。研究对象包括1988年至1991年我们数据库中所有经超声检查发现有此征象的异常胎儿（共23例）。发现12例胎儿患有脊髓脊膜膨出，6例患有脑膨出。5例有柠檬征的胎儿表现出各种不涉及神经管的结构异常。这一超声检查发现似乎并不局限于脊髓脊膜膨出病例。
