Ward R D
Biochem Genet. 1977 Feb;15(1-2):123-35. doi: 10.1007/BF00484555.
The need for proteins to maintain particular quarternary structures constrains variability in amino acid sequence. Monomeric enzymes are then expected to be more variable than dimeric forms, which in turn are expected to be more variable than tetrameric forms. These predictions are confirmed by analysis of available data on enzyme variation. Theories relating enzyme heterozygosity to metabolic function are discussed in the light of these findings.
蛋白质维持特定四级结构的需求限制了氨基酸序列的变异性。因此，预计单体酶比二聚体形式更具变异性，而二聚体形式又预计比四聚体形式更具变异性。对酶变异现有数据的分析证实了这些预测。根据这些发现，讨论了将酶杂合性与代谢功能相关联的理论。
