[唐氏综合征合并室间隔缺损的外科治疗]

[Surgical treatment of ventricular septal defect associated with Down syndrome].

作者信息

Okada H, Tsuboi H, Nishi K, Matsumoto N, Gohra H, Katou T, Fujimura Y, Miyamoto M, Esato K

机构信息

First Department of Surgery, Yamaguchi University School of Medicine, Japan.

出版信息

Kyobu Geka. 1993 May;46(5):396-8.

PMID:8492489

Abstract

Twelve patients with ventricular septal defect with Down syndrome (Down group) underwent cardiac surgery. As they had pulmonary hypertension (Pp/Ps > or = 0.5), we chose twenty patients who had pulmonary hypertension (Pp/Ps > or = 0.5) with ventricular septal defect without Down syndrome as control group. After cardiac surgery, Pp/Ps in Down group decreased significantly from 0.81 +/- 0.14 to 0.48 +/- 0.25 (p < 0.01). Cardiac index (l/min/m2) between 24 hours after operation was 3.3-3.8 in Down and 4.1-4.8 in control group (NS). Oxygenation index (mmHg) between 24 hours after operation was 211-266 in Down and 230-314 in control group (NS). Eleven out of 12 patients in Down group had good operative result. One patient was complicated with post-operative pulmonary hypertensive crisis. Low output syndrome and death were not encountered in Down group. We were satisfied with operative results and encourage surgical treatment for ventricular septal defect with Down syndrome.

摘要

12例患有唐氏综合征的室间隔缺损患者（唐氏组）接受了心脏手术。由于他们患有肺动脉高压（Pp/Ps≥0.5），我们选择了20例患有肺动脉高压（Pp/Ps≥0.5）且无唐氏综合征的室间隔缺损患者作为对照组。心脏手术后，唐氏组的Pp/Ps从0.81±0.14显著降至0.48±0.25（p<0.01）。术后24小时内，唐氏组的心脏指数（升/分钟/平方米）为3.3 - 3.8，对照组为4.1 - 4.8（无显著差异）。术后24小时内，唐氏组的氧合指数（毫米汞柱）为211 - 266，对照组为230 - 314（无显著差异）。唐氏组12例患者中有11例手术效果良好。1例患者术后并发肺动脉高压危象。唐氏组未出现低心排血量综合征和死亡情况。我们对手术结果满意，并鼓励对患有唐氏综合征的室间隔缺损患者进行手术治疗。