Rao K N, Virji M A, Moraca M A, Diven W F, Martin T G, Schneider S M
Department of Pathology, University of Pittsburgh School of Medicine, PA 15213.
J Anal Toxicol. 1993 Mar-Apr;17(2):99-102. doi: 10.1093/jat/17.2.99.
Accidental or intentional chloroform poisoning is rare, but a few such cases have been reported in literature. We report here a successful management of acute chloroform toxicity in a 33-year-old white female who attempted suicide by injecting one half milliliter of chloroform, followed by drinking half a cup the next morning. Plasma chloroform levels, measured by headspace gas chromatography declined rapidly. Sequential measurement of biomarkers in serum for liver cell necrosis, liver function, and liver regeneration indicated the presence of initial liver damage followed by recovery. These results suggest that in addition to biomarkers for liver cell necrosis, serial determinations of markers for liver regeneration provide objective evidence for recovery from chloroform poisoning and possibly other hepatotoxins.
意外或故意的氯仿中毒很少见，但文献中已有一些此类病例的报道。我们在此报告一例33岁白人女性急性氯仿中毒的成功救治案例，该患者试图通过注射半毫升氯仿自杀，次日早晨又喝下半杯氯仿。通过顶空气相色谱法测定的血浆氯仿水平迅速下降。对血清中肝细胞坏死、肝功能和肝再生的生物标志物进行连续检测，结果表明最初存在肝损伤，随后恢复。这些结果表明，除了肝细胞坏死的生物标志物外，连续测定肝再生标志物可为氯仿中毒及可能的其他肝毒素中毒的恢复提供客观证据。
