Kasahara K, Nagatani T, Takao K, Hashimoto S
First Lab. for Pharmacological Research, Asahi Chemical Industry Co., Ltd., Miyazaki, Japan.
Life Sci. 1993;52(22):1741-9. doi: 10.1016/0024-3205(93)90462-c.
The antidepressant-like effect of 8-hydroxy-2-(di-n-propylamino)tetralin(8-OH-DPAT), a selective 5-HT1A receptor agonist, was studied in the forced swimming wheel test in reserpine-treated mice. 8-OH-DPAT and the antidepressant imipramine, dose-dependently increased the number of turns of a water wheel made by mice. This effect of imipramine (30 mg/kg, i.p.) was enhanced by reserpine treatment 24 hr before the test. The effect of 8-OH-DPAT (0.3 mg/kg, i.p.) was also enhanced in reserpine-treated mice. This enhanced effect of 8-OH-DPAT was blocked by pretreatment with the 5-HT1A receptor antagonists, (-)-propranolol (3 mg/kg, i.p.) and NAN-190 (1 mg/kg, i.p.), but was not blocked by a beta-blocker, (-)-atenolol (3 mg/kg, i.p.). 8-OH-DPAT did not affect locomotor activity in the reserpinized mice and did not affect the reduction of monoamine content induced by reserpine. These results suggest that the effect of 8-OH-DPAT in increasing the number of turns of the wheel made by mice was exerted through a 5-HT1A receptor and that this effect did not reflect only changes in the locomotor activity of the mice.
在利血平处理的小鼠的强迫游泳轮试验中，研究了选择性5-羟色胺1A（5-HT1A）受体激动剂8-羟基-2-（二正丙基氨基）四氢萘（8-OH-DPAT）的抗抑郁样作用。8-OH-DPAT和抗抑郁药丙咪嗪剂量依赖性地增加了小鼠转动水轮的次数。在试验前24小时用利血平处理可增强丙咪嗪（30毫克/千克，腹腔注射）的这种作用。在利血平处理的小鼠中，8-OH-DPAT（0.3毫克/千克，腹腔注射）的作用也增强。8-OH-DPAT的这种增强作用被5-HT1A受体拮抗剂（-）-普萘洛尔（3毫克/千克，腹腔注射）和NAN-190（1毫克/千克，腹腔注射）预处理所阻断，但不被β-阻滞剂（-）-阿替洛尔（3毫克/千克，腹腔注射）阻断。8-OH-DPAT不影响利血平化小鼠的运动活性，也不影响利血平诱导的单胺含量的降低。这些结果表明，8-OH-DPAT增加小鼠转动水轮次数的作用是通过5-HT1A受体发挥的，并且这种作用不仅仅反映了小鼠运动活性的变化。
