高剂量伊维菌素对马圆线虫包囊幼虫的疗效评估。

Evaluation of ivermectin at an elevated dose against encysted equine cyathostome larvae.

作者信息

Klei T R, Chapman M R, French D D, Taylor H W

机构信息

Department of Veterinary Science, Louisiana State University Agricultural Center, Baton Rouge 70803.

出版信息

Vet Parasitol. 1993 Mar;47(1-2):99-106. doi: 10.1016/0304-4017(93)90180-u.

DOI:10.1016/0304-4017(93)90180-u

PMID:8493773

Abstract

The efficacy of a high dose of ivermectin (1.0 mg per kg Eqvalan liquid drench) on encysted cyathostomes was tested in a controlled study using 12 adult ponies with naturally acquired cyathostome infections. Six treated ponies and six non-treated controls were held in separate stalls for a period of 5 weeks. Cyathostome burdens, which included lumenal larvae, adults and encysted larvae, were determined at necropsy. The viability of encysted larvae, based on morphologic integrity, was assessed by observation of mural transillumination and by the histologic appearance of 12 larvae per pony. Efficacy against adult cyathostomes was 99.9%. Lumenal cyathostome larval numbers were reduced by 87%. Numbers of encysted cyathostome larvae, identified by transillumination of the large intestine, were reduced by 35%. However, this reduction was not statistically significant (P > 0.05) and differences in viability of encysted larvae were not observed. The data strongly indicated that ivermectin has little demonstrable effect on encysted equine cyathostomes.

摘要

在一项对照研究中，使用12匹自然感染杯状线虫的成年小马，测试了高剂量伊维菌素（每千克Equvalan液剂1.0毫克）对包囊期杯状线虫的疗效。6匹接受治疗的小马和6匹未治疗的对照马被分别安置在单独的畜栏中5周。在尸检时确定杯状线虫负荷，包括肠腔幼虫、成虫和包囊幼虫。基于形态完整性，通过观察肠壁透照和每匹小马12条幼虫的组织学外观来评估包囊幼虫的活力。对成虫杯状线虫的疗效为99.9%。肠腔杯状线虫幼虫数量减少了87%。通过大肠透照鉴定的包囊期杯状线虫幼虫数量减少了35%。然而，这种减少没有统计学意义（P>0.05），并且未观察到包囊幼虫活力的差异。数据强烈表明，伊维菌素对包囊期马杯状线虫几乎没有明显效果。