Simpson S G, Folstein S E, Meyers D A, McMahon F J, Brusco D M, DePaulo J R
Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD.
Am J Psychiatry. 1993 Jun;150(6):901-3. doi: 10.1176/ajp.150.6.901.
The purpose of this study was to compare the pattern of affective psychopathology in families ascertained for genetic linkage studies through bipolar I probands to that in families ascertained through bipolar II probands.
All available first-degree relatives (N = 266) of 48 bipolar I and eight bipolar II probands were interviewed with the Schedule for Affective Disorders and Schizophrenia--Lifetime Version by one of two psychiatrists who had attained high interrater reliability for bipolar II disorder and other diagnoses.
Bipolar II disorder was the most common affective disorder in both family sets. Forty percent of the 47 first-degree relatives of the bipolar II probands and 22% of the 219 first-degree relatives of the bipolar I probands were diagnosed with bipolar II disorder. On the other hand, only one bipolar I relative was found in the bipolar II families.
Bipolar II disorder was the most prevalent affected phenotype in both bipolar I and bipolar II families and was the only expressed phenotype in half of the bipolar II families. This suggests that bipolar II disorder is genetically related to but less complex than bipolar I disorder. Accurate diagnosis of bipolar II disorder may be crucial in finding the genetic loci underlying bipolar disorders generally.
本研究旨在比较通过双相 I 型先证者确定用于基因连锁研究的家庭与通过双相 II 型先证者确定的家庭中情感精神病理学模式。
48 名双相 I 型和 8 名双相 II 型先证者的所有可获得的一级亲属（N = 266）由两名精神科医生之一使用《情感障碍与精神分裂症问卷——终生版》进行访谈，这两名医生在双相 II 型障碍和其他诊断方面具有较高的评分者间信度。
双相 II 型障碍是两组家庭中最常见的情感障碍。双相 II 型先证者的 47 名一级亲属中有 40%以及双相 I 型先证者的 219 名一级亲属中有 22%被诊断为双相 II 型障碍。另一方面，在双相 II 型家庭中仅发现 1 名双相 I 型亲属。
双相 II 型障碍是双相 I 型和双相 II 型家庭中最普遍的受影响表型，并且是一半双相 II 型家庭中唯一表现出的表型。这表明双相 II 型障碍与双相 I 型障碍在遗传上相关，但比双相 I 型障碍更简单。准确诊断双相 II 型障碍对于总体上找到双相情感障碍的基因位点可能至关重要。
