Shearer E S, Russell G N
University Department of Anaesthesia, Royal Liverpool University Hospital.
Anaesthesia. 1993 Apr;48(4):293-6. doi: 10.1111/j.1365-2044.1993.tb06945.x.
Cholinesterase activity was determined in 18 patients who had undergone either hypothermic (n = 9) or normothermic (n = 9) cardiopulmonary bypass. The anaesthetic technique was standardised to avoid agents known to affect cholinesterase. Activity was determined in blood samples taken before the induction of anaesthesia, during cardiopulmonary bypass and for at least 7 days postoperatively. In six patients cholinesterase activity was also measured at 6 weeks postoperatively. All the patients were of normal cholinesterase genotype. In both groups cholinesterase activity fell by approximately 60% coinciding with the start of cardiopulmonary bypass, from a mean of 5976 to 2636 IU.l-1 in the hypothermic group, and from 5901 to 2615 IU.l-1 in the normothermic group (p < 0.001 in both instances) (normal range 4300-10,500 IU.l-1). Cholinesterase activity remained at this reduced level for at least 7 days postoperatively. By 6 weeks, activity had returned to within 7% of pre-induction values. There were no differences in cholinesterase activity between the hypothermic and normothermic groups at any of the sampling times.
对18例接受低温（n = 9）或常温（n = 9）体外循环的患者测定了胆碱酯酶活性。麻醉技术标准化，以避免使用已知会影响胆碱酯酶的药物。在麻醉诱导前、体外循环期间以及术后至少7天采集的血样中测定活性。在6例患者中，术后6周也测量了胆碱酯酶活性。所有患者的胆碱酯酶基因型均正常。两组患者的胆碱酯酶活性在体外循环开始时均下降了约60%，低温组从平均5976 IU·l-1降至2636 IU·l-1，常温组从5901 IU·l-1降至2615 IU·l-1（两种情况p均<0.001）（正常范围4300 - 10500 IU·l-1）。术后至少7天胆碱酯酶活性维持在这一降低水平。到6周时，活性已恢复到诱导前值的7%以内。在任何采样时间，低温组和常温组之间的胆碱酯酶活性均无差异。
