Pfaller M A, Barry A L, Fuchs P C
Oregon Health Sciences University, Portland 97201.
Antimicrob Agents Chemother. 1993 Apr;37(4):893-5. doi: 10.1128/AAC.37.4.893.
Ro 40-6890, the active metabolite of Ro 41-3399, was tested against 391 gram-negative and gram-positive clinical isolates. Ro 40-6890 was active against members of the family Enterobacteriaceae, Moraxella catarrhalis, pneumococci, other Streptococcus spp., and methicillin-susceptible staphylococci. Preliminary disk diffusion interpretive zone criteria were calculated for 5-, 10-, and 30-micrograms Ro 40-6890 disks and several possible MIC susceptibility breakpoints. We recommend the use of the 5-micrograms disk and suggest that the following zone diameters be used as breakpoints in clinical trials: susceptible, > or = 21 mm (MIC, < or = 1 microgram/ml); intermediate, 18 to 20 mm (MIC, 2 micrograms/ml); and resistant, < or = 17 mm (MIC, > or = 4 micrograms/ml).
Ro 40-6890是Ro 41-3399的活性代谢产物，对391株革兰氏阴性和革兰氏阳性临床分离株进行了测试。Ro 40-6890对肠杆菌科细菌、卡他莫拉菌、肺炎球菌、其他链球菌属以及对甲氧西林敏感的葡萄球菌具有活性。针对5微克、10微克和30微克的Ro 40-6890药敏纸片以及几个可能的最低抑菌浓度（MIC）敏感断点计算了初步的纸片扩散法解释性抑菌圈标准。我们建议使用5微克的药敏纸片，并建议在临床试验中以下抑菌圈直径用作断点：敏感，≥21毫米（MIC，≤1微克/毫升）；中介，18至20毫米（MIC，2微克/毫升）；耐药，≤17毫米（MIC，≥4微克/毫升）。
