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Platelet aggregation inhibiting and anticoagulant effects of oligoamines, XX: 4,4',4''-(1,3,5)-benzene-tris-sydnone imines.

作者信息

Rehse K, Martens A

机构信息

Institut für Pharmazie der Freien Universität Berlin.

出版信息

Arch Pharm (Weinheim). 1993 Apr;326(4):217-9. doi: 10.1002/ardp.19933260407.

DOI:10.1002/ardp.19933260407
PMID:8494483
Abstract

The synthesis of ten tris-sydnone imine derivatives, unknown up to now, is described. All compounds are alkyl or arylalkyl substituted in 3-position of the sydnone imine. The most powerful agent was the 3-propyl derivative 6c. It inhibits the aggregation of human platelets induced by collagen in a concentration of 1 mumol/L half maximally. Its N-ethoxycarbonyl derivative 7c, which was designed as a prodrug, showed only small antithrombotic effects in rats. The reason for this low degree of activity is discussed.

摘要

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