Schiavi R C, White D, Mandeli J, Schreiner-Engel P
Department of Psychiatry, Mount Sinai School of Medicine, New York, New York 10029.
Arch Sex Behav. 1993 Jun;22(3):207-15. doi: 10.1007/BF01541766.
There is no information on the relationship between endogenous pituitary and gonadal hormones and nocturnal penile tumescence (NPT) in healthy aging men. Sixty-seven married volunteers ages 45-74 years were studied in the sleep laboratory for 4 nights with the last night devoted to sequential blood sampling every 20 min. Bioavailable testosterone (bT) correlated significantly with several NPT measures while total testosterone, estradiol, LH, and prolactin were mostly unrelated to NPT. All bT-NPT correlations lost their significance after adjustment by multiple regression for the effect of age on both bT and NPT variables in the total subject sample. Analysis of bT-NPT relations by age groups revealed a significant association between bT and duration NPT in men ages 55 to 64 years, but no statistical relations in younger and older age groups. Changes in the central threshold of activation of NPT as age progresses may explain the age-dependent effect of bT in sleep erections.
关于健康老年男性体内垂体和性腺激素与夜间阴茎勃起（NPT）之间的关系尚无相关信息。67名年龄在45至74岁的已婚志愿者在睡眠实验室接受了4晚的研究，最后一晚每隔20分钟进行一次连续血液采样。生物可利用睾酮（bT）与多项NPT指标显著相关，而总睾酮、雌二醇、促黄体生成素（LH）和催乳素大多与NPT无关。在对总体样本中年龄对bT和NPT变量的影响进行多元回归调整后，所有bT与NPT的相关性均失去了显著性。按年龄组分析bT与NPT的关系发现，55至64岁男性的bT与NPT持续时间之间存在显著关联，但在较年轻和较年长年龄组中无统计学关系。随着年龄增长，NPT激活中枢阈值的变化可能解释了bT对睡眠勃起的年龄依赖性影响。
