含2'-氨基-2'-脱氧嘧啶核苷的寡脱氧核糖核苷酸
[Oligodeoxyribonucleotides containing 2'-amino-2'-deoxypyrimidine nucleosides].
作者信息
Kuznetsova L G, Romanova E A, Volkov E M, Tashlitskiĭ V N, Oretskaia T S, Krynetskaia N F, Shabarova Z A
出版信息
Bioorg Khim. 1993 Apr;19(4):455-66.
PMID:8494568
Abstract
The synthesis, by means of the standard phosphoramidite chemistry, of modified oligodeoxynucleotides (5-20 residues) containing 2'-amino-2'-deoxypyrimidine nucleosides has been carried out, and their ability to form duplexes with complementary DNA has been investigated. A high reactivity of such compounds in N-acylation was shown.
摘要
通过标准亚磷酰胺化学方法合成了含有2'-氨基-2'-脱氧嘧啶核苷的修饰寡脱氧核苷酸（5 - 20个残基），并研究了它们与互补DNA形成双链体的能力。结果表明这类化合物在N-酰化反应中具有高反应活性。
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