López A, Hinojosa J, Miralles A, Primo J, Bermúdez J D
Hospital de Sagunto, Universitat de València.
Rev Esp Enferm Dig. 1993 Apr;83(4):235-9.
In previous work we defined the normal values of faecal alpha-1 antitrypsin (A1ATF) and their plasmatic clearance (CLAT) in 25 healthy patients. The aim of the present study is to compare these previous results with new results obtained when we applied this test to 30 patients with Crohn's disease (CD). We also show the good performance of the mentioned tests as indicators of the intestinal inflammatory activity. We compare the values of A1ATF and CLAT of healthy patients with those of CD patients. We also compare the Crohn's Disease Activity Index (CDAI) and Simple Index between active and inactive CD patients. Our results show significant differences between A1ATF excretion and CLAT as measured in healthy and CD patients. The relationship between those parameters could be explained by the equation CLAT = 0.325 x A1ATF. Active and inactive CD patients only differ significantly with respect to their leucocytes and C reactive protein values. In our group the A1ATF excretion is larger in CD patients with colonic disease.
在之前的研究中，我们测定了25名健康受试者粪便α1-抗胰蛋白酶（A1ATF）的正常参考值及其血浆清除率（CLAT）。本研究旨在将上述结果与应用该检测方法检测30例克罗恩病（CD）患者的新结果进行比较。我们还证实了上述检测作为肠道炎症活动指标的良好性能。我们比较了健康受试者与CD患者的A1ATF和CLAT值。我们还比较了活动期与非活动期CD患者的克罗恩病活动指数（CDAI）和简易指数。我们的结果显示，健康受试者与CD患者的A1ATF排泄和CLAT存在显著差异。这些参数之间的关系可用公式CLAT = 0.325×A1ATF表示。活动期与非活动期CD患者仅在白细胞和C反应蛋白值上存在显著差异。在我们的研究队列中，结肠病变的CD患者A1ATF排泄量更高。
