Childs W J, Goldstraw P, Nicholls J E, Dearnaley D P, Horwich A
Oncology Centre, Auckland Hospital, New Zealand.
Br J Cancer. 1993 May;67(5):1098-101. doi: 10.1038/bjc.1993.201.
A retrospective analysis was performed of 18 patients with primary malignant germ cell tumours of the mediastinum treated with platinum-based chemotherapy between 1977 and 1990. All seven patients with pure seminoma were treated initially with chemotherapy and four of these patients received additional mediastinal radiotherapy. Only one patient relapsed; his initial therapy had included radiotherapy and single-agent carboplatin and he was successfully salvaged with combination chemotherapy. With a follow-up of 11 to 117 months (median 41 months) all seven patients with seminoma remain alive and disease free giving an overall survival of 100%. Eleven patients had malignant non seminoma; following chemotherapy eight of these had elective surgical resection of residual mediastinal masses. Complete remission was achieved in nine (82%) patients, however, one of these patients died from bleomycin pneumonitis. With a follow-up of 12 to 113 months (median 55 months) eight of 11 (73%) patients with malignant mediastinal teratoma remain alive and disease free.
对1977年至1990年间接受铂类化疗的18例原发性纵隔恶性生殖细胞肿瘤患者进行了回顾性分析。所有7例纯精原细胞瘤患者最初均接受化疗，其中4例患者接受了额外的纵隔放疗。仅1例患者复发；其初始治疗包括放疗和单药卡铂，他通过联合化疗成功挽救。随访11至117个月（中位41个月），所有7例精原细胞瘤患者均存活且无疾病，总生存率为100%。11例患者为恶性非精原细胞瘤；化疗后，其中8例患者接受了残余纵隔肿块的选择性手术切除。9例（82%）患者实现完全缓解，然而，其中1例患者死于博来霉素肺炎。随访12至113个月（中位55个月），11例恶性纵隔畸胎瘤患者中有8例（73%）存活且无疾病。
