Rosen A, Sevelda P, Klein M, Dobianer K, Hruza C, Czerwenka K, Hanak H, Vavra N, Salzer H, Leodolter S
Department of Gynecology and Obstetrics, Hanusch Medical Center, Vienna, Austria.
Br J Cancer. 1993 May;67(5):1122-5. doi: 10.1038/bjc.1993.206.
Estimation of FGF-3 oncogene amplification in DNA samples extracted from paraffin embedded sections of 136 ovarian cancer samples was carried out by a quantitative PCR method. The aim of this study was to elucidate a possible association of FGF-3 copy numbers with established prognostic factors such as age, histology, FIGO stage, grading, postoperative residual tumour mass, ascites, hormone receptor content and preoperative CA 125 serum levels. In addition, correlation of FGF-3 amplification with overall survival of the patients was assessed. There was a borderline positive correlation between preoperative CA 125 serum levels and the degree of amplification of the FGF-3 gene (P = 0.06). A statistically significant association of FIGO-stage with FGF-3 copy number could be found (P = 0.008). No correlation between FGF-3 amplification and overall survival was noted. The data combine to suggest that FGF-3 is an indicator of aggressiveness of ovarian cancer.
采用定量PCR方法对从136份卵巢癌样本石蜡包埋切片中提取的DNA样本进行FGF - 3癌基因扩增评估。本研究的目的是阐明FGF - 3拷贝数与已确定的预后因素如年龄、组织学、国际妇产科联盟（FIGO）分期、分级、术后残留肿瘤肿块、腹水、激素受体含量和术前CA 125血清水平之间可能存在的关联。此外，还评估了FGF - 3扩增与患者总生存期的相关性。术前CA 125血清水平与FGF - 3基因扩增程度之间存在临界正相关（P = 0.06）。发现FIGO分期与FGF - 3拷贝数之间存在统计学显著关联（P = 0.008）。未观察到FGF - 3扩增与总生存期之间的相关性。这些数据综合表明FGF - 3是卵巢癌侵袭性的一个指标。
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