Rasschaert J, Malaisse W J
Laboratory of Experimental Medicine, Brussels Free University, Belgium.
Biochem Mol Biol Int. 1993 Feb;29(2):369-74.
In several animal models of non-insulin-dependent diabetes, a decreased activity of FAD-linked glycerophosphate dehydrogenase was recently documented in pancreatic islet, but not liver, homogenates. The present study reveals that, on the contrary, the activity of the same mitochondrial enzyme is increased in islet, but not liver or spleen, homogenates of BB, as compared to BW, rats examined before the onset of severe hyperglycemia in this animal model of autoimmune insulin-dependent diabetes.
在几种非胰岛素依赖型糖尿病动物模型中，最近有文献报道，在胰岛匀浆中，与黄素腺嘌呤二核苷酸（FAD）相关的甘油磷酸脱氢酶活性降低，但在肝脏匀浆中未出现这种情况。然而，本研究表明，在自身免疫性胰岛素依赖型糖尿病动物模型中，在严重高血糖发作之前检查的BB大鼠与BW大鼠相比，该线粒体酶在胰岛匀浆中的活性增加，而在肝脏或脾脏匀浆中未增加。
