萘酚平处理的雄性大鼠肝脏、回肠和肾脏中细胞色素P-450同工酶CYP4A1的免疫电子显微镜定位
Immunoelectron microscopic localization of cytochrome P-450 isoenzyme CYP4A1 in liver, ileum and kidney of nafenopin treated male rats.
作者信息
Persohn E, Thomas H, Waechter F
机构信息
Ciba-Geigy Limited, Cell Biology Group/Toxicology Services, Basle/Switzerland.
出版信息
Cell Biol Int. 1993 Jan;17(1):99-103. doi: 10.1006/cbir.1993.1010.
A monoclonal antibody raised against and specific for cytochrome P-450 isoenzyme CYP4A1 was used to investigate the subcellular distribution of this enzyme in the liver, kidney and ileum of nafenopin treated rats by means of immunoelectron microscopy. In the liver and kidney, labelling was restricted to peroxisomes and mitochondria of hepatocytes and proximal tubular epithelial cells whereas in ileum, immunolabelling was exclusively detected in mitochondria of absorptive cells.
一种针对细胞色素P-450同工酶CYP4A1产生且对其具有特异性的单克隆抗体，通过免疫电子显微镜技术用于研究经萘酚平处理的大鼠肝脏、肾脏和回肠中该酶的亚细胞分布。在肝脏和肾脏中，标记仅限于肝细胞和近端肾小管上皮细胞的过氧化物酶体和线粒体，而在回肠中，仅在吸收细胞的线粒体中检测到免疫标记。
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