Biggs M W, Eiselein J E
Medical Department, Lawrence Livermore National Laboratory, California.
Cancer Lett. 1993 Apr 30;69(2):133-7. doi: 10.1016/0304-3835(93)90165-6.
Significant remissions in autochthonous mammary tumors in A/Strong mice were effected in 45% of treated animals with a vaccine prepared with an enterovirus plus cyclophosphamide. Three methods of vaccine preparation were examined. Only one was effective although all three contained viable viruses. The data are consistent with the interpretation that the effective vaccine stimulated the host reticuloendothelial (RE) system differentially so that partial destruction with cyclophosphamide resulted in the reprograming of the RE system in favor of host control.
用肠道病毒加环磷酰胺制备的疫苗，使45%接受治疗的A/Strong小鼠的自发性乳腺肿瘤显著缓解。研究了三种疫苗制备方法。尽管三种方法都含有活病毒，但只有一种有效。这些数据与以下解释一致：有效的疫苗以不同方式刺激宿主网状内皮（RE）系统，因此用环磷酰胺进行部分破坏会导致RE系统重新编程，有利于宿主控制。
