Triebig G, Lang C
Institute and Policlinic of Occupational and Social Medicine, University of Heidelberg, Germany.
Environ Res. 1993 May;61(2):239-50. doi: 10.1006/enrs.1993.1068.
The application of neuroimaging techniques such as cerebral blood flow (CBF), single photon emission tomography (SPECT), X-ray computed tomography (CAT), and magnetic resonance imaging (MRI) on solvent-exposed workers and patients with toxic encephalopathy results in different and somewhat inconclusive pictures. The aim of this paper is to therefore critically review the current knowledge on chronic neurotoxicity of solvent exposures with respect to neuroimaging technique. CAT measurements of 86 house or construction painters, 82 spray painters, and 81 nonpainters showed no abnormal diffuse brain atrophy due to chronic solvent exposure after controlling for confounding variables such as age, alcohol consumption, or former disease. Correlation analyses did not show any consistent, biologically plausible exposure-effect relationship. Neuropsychologic test results did not correlate significantly with CAT parameters, whereas a strong age dependency exists. It is concluded that long-term exposure to solvent concentrations not exceeding permissible occupational limit values does not cause increased brain atrophy.
将诸如脑血流量（CBF）、单光子发射断层扫描（SPECT）、X射线计算机断层扫描（CAT）和磁共振成像（MRI）等神经成像技术应用于接触溶剂的工人和患有中毒性脑病的患者，会得出不同且有些不确定的结果。因此，本文的目的是严格审查目前关于溶剂暴露对神经成像技术的慢性神经毒性的认识。对86名房屋或建筑油漆工、82名喷漆工和81名非油漆工进行的CAT测量显示，在控制了年龄、饮酒量或既往疾病等混杂变量后，慢性溶剂暴露并未导致异常的弥漫性脑萎缩。相关性分析未显示任何一致的、生物学上合理的暴露-效应关系。神经心理学测试结果与CAT参数无显著相关性，而存在强烈的年龄依赖性。得出的结论是，长期暴露于不超过职业允许限值的溶剂浓度不会导致脑萎缩增加。
