Hee J P, MacNaughton J, Bangah M, Zissimos M, McCloud P I, Healy D L, Burger H G
Prince Henry's Institute of Medical Research, Monash Medical Center, Clayton, Victoria, Australia.
J Clin Endocrinol Metab. 1993 May;76(5):1340-3. doi: 10.1210/jcem.76.5.8496327.
To determine whether FSH is a physiological regulator of the serum immunoreactive inhibin (INH) concentration during the follicular phase of the normal menstrual cycle, purified FSH (Metrodin) was administered in doses of 100 IU (n = 6), 150 IU (n = 5), and 200 IU (n = 5) to normal, regularly cycling volunteers between days 3-7 of the menstrual cycle. A control group (n = 5) received normal saline. There was a linear dose-related increase in serum INH (and in serum FSH) in response to the three doses of FSH, with 200 IU leading to a 107% increase in INH and a 68% increase in FSH. Serum estradiol rose in response to the two higher doses of FSH. There was a significant correlation between the actual increases in INH and estradiol (r = 0.53; P < 0.01). It was concluded that FSH stimulates INH in the follicular phase of the normal menstrual cycle, consistent with a physiological role for FSH in the regulation of granulosa cell production of inhibin.
为了确定在正常月经周期的卵泡期促卵泡激素（FSH）是否是血清免疫反应性抑制素（INH）浓度的生理调节因子，在月经周期第3至7天，将纯化的促卵泡激素（Metrodin）以100 IU（n = 6）、150 IU（n = 5）和200 IU（n = 5）的剂量给予正常、月经周期规律的志愿者。对照组（n = 5）接受生理盐水。随着三种剂量促卵泡激素的给予，血清抑制素（以及血清促卵泡激素）呈剂量相关的线性增加，200 IU剂量导致抑制素增加107%，促卵泡激素增加68%。血清雌二醇随着较高的两种促卵泡激素剂量而升高。抑制素和雌二醇的实际增加之间存在显著相关性（r = 0.53；P < 0.01）。得出的结论是，在正常月经周期的卵泡期促卵泡激素刺激抑制素，这与促卵泡激素在调节颗粒细胞抑制素产生中的生理作用一致。
