结节病中的人类白细胞抗原
HLA antigens in sarcoidosis.
作者信息
Brewerton D A, Cockburn C, James D C, James D G, Neville E
出版信息
Clin Exp Immunol. 1977 Feb;27(2):227-9.
Abstract
The HLA antigens were identified in sixty-five patients with sarcoidosis, comprising forty-five with uveitis, twelve with erythema nodosum and eight with arthritis. In the group with arthritis, B8 was present in seven of eight (P = 0-0016) and the haplotype 1,8 in five of eight (P = 0-0053). A1 was present in 44% with uveitis (P = 0-04). There was no other significant disturbance of antigen frequencies in uveitis or in erythema nodosum, but it was noteworthy that B27 was present in only two patients with uveitis.
摘要
在65例结节病患者中鉴定出HLA抗原，其中45例患有葡萄膜炎，12例患有结节性红斑，8例患有关节炎。在关节炎组中，8例中有7例存在B8（P = 0.0016），8例中有5例存在单倍型1,8（P = 0.0053）。44%的葡萄膜炎患者存在A1（P = 0.04）。葡萄膜炎或结节性红斑患者的抗原频率没有其他显著异常，但值得注意的是，只有2例葡萄膜炎患者存在B27。
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