Petri M, Allbritton J
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD.
J Rheumatol. 1993 Apr;20(4):650-6.
To determine the frequency of pregnancy loss, preterm birth, and therapeutic abortion in patients with systemic lupus erythematosus (SLE) versus controls.
The outcome of lupus pregnancy was determined in the largest retrospective case-control study to date, involving 203 patients with SLE with 481 pregnancies, 166 "best friends" with 356 pregnancies and 177 relatives with 566 pregnancies.
Pregnancy loss (spontaneous abortion, miscarriage, or stillbirth) was more common in lupus pregnancies (21%) than in pregnancies in friends (14%, p = 0.01) or in relatives (8%, p < or = 0.0001) and was more common after the diagnosis of SLE than before (27 19%, p = 0.04). Preterm birth (< or = 36 weeks) was more common in lupus pregnancies (12%) than in pregnancies in friends (4%, p < or = 0.0001) or in relatives (4%, p < or = 0.0001) and was more common after the diagnosis of SLE than before (24 vs 6%, p < or = 0.0001). Preterm birth in lupus pregnancies after the diagnosis of SLE was associated with nonhigh school graduates (p = 0.001), Raynaud's phenomenon (p = 0.007), and hypertension requiring treatment (p = 0.01).
We conclude that both pregnancy loss and preterm birth are significantly increased in lupus pregnancy versus control pregnancy and that these pregnancy outcomes are more common after the diagnosis of SLE.
确定系统性红斑狼疮（SLE）患者与对照组相比，妊娠丢失、早产和治疗性流产的发生率。
在迄今为止最大规模的回顾性病例对照研究中确定狼疮妊娠的结局，该研究纳入203例SLE患者的481次妊娠、166名“闺蜜”的356次妊娠以及177名亲属的566次妊娠。
狼疮妊娠中妊娠丢失（自然流产、流产或死产）比闺蜜妊娠（14%，p = 0.01）或亲属妊娠（8%，p≤0.0001）更常见，且SLE诊断后比诊断前更常见（27%对19%，p = 0.04）。早产（≤36周）在狼疮妊娠中（12%）比闺蜜妊娠（4%，p≤0.0001）或亲属妊娠（4%，p≤0.0001）更常见，且SLE诊断后比诊断前更常见（24%对6%，p≤0.0001）。SLE诊断后狼疮妊娠中的早产与非高中毕业生（p = 0.001）、雷诺现象（p = 0.007）以及需要治疗的高血压（p = 0.01）相关。
我们得出结论，与对照妊娠相比，狼疮妊娠中妊娠丢失和早产均显著增加，且这些妊娠结局在SLE诊断后更常见。
