Baethge B A, Work J, Landreneau M D, McDonald J C
Department of Medicine, Louisiana State University Medical Center in Shreveport.
J Rheumatol. 1993 Apr;20(4):718-20.
Hyperuricemia and gout have been associated with cyclosporine A (CyA) therapy in transplant recipients. We describe 4 patients who developed severe tophaceous gout after renal transplantation. All of the patients received CyA, prednisone, and diuretic therapy. Three had episodes of allograft rejection. No patient had the diagnosis of gout before transplantation. All developed tophi within 5 years of the first attack of gout. Management of these patients has been difficult due to renal insufficiency, drug interactions and toxicity. Clinicians should be aware that tophaceous gout can occur rapidly in CyA treated transplant recipients.
高尿酸血症和痛风与移植受者接受环孢素A（CyA）治疗有关。我们描述了4例肾移植后发生严重痛风石性痛风的患者。所有患者均接受了CyA、泼尼松和利尿剂治疗。3例发生过移植肾排斥反应。所有患者在移植前均未诊断为痛风。所有患者在痛风首次发作后的5年内均出现了痛风石。由于肾功能不全、药物相互作用和毒性，这些患者的治疗一直很困难。临床医生应意识到，接受CyA治疗的移植受者可能迅速发生痛风石性痛风。
