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(S)-N-tert-butyl-3-(4-(2-methoxyphenyl)-piperazin-1-yl)-2-phenylpropanamide [(S)-WAY-100135]: a selective antagonist at presynaptic and postsynaptic 5-HT1A receptors.

作者信息

Cliffe I A, Brightwell C I, Fletcher A, Forster E A, Mansell H L, Reilly Y, Routledge C, White A C

机构信息

Department of Medicinal Chemistry, Wyeth Research (UK), Taplow, Berkshire, England.

出版信息

J Med Chem. 1993 May 14;36(10):1509-10. doi: 10.1021/jm00062a028.

DOI:10.1021/jm00062a028
PMID:8496920
Abstract
摘要

相似文献

1
(S)-N-tert-butyl-3-(4-(2-methoxyphenyl)-piperazin-1-yl)-2-phenylpropanamide [(S)-WAY-100135]: a selective antagonist at presynaptic and postsynaptic 5-HT1A receptors.
J Med Chem. 1993 May 14;36(10):1509-10. doi: 10.1021/jm00062a028.
2
MP-3022, a new putative antagonist at pre- and postsynaptic 5-HT1A receptors.MP - 3022，一种新型的突触前和突触后5 - HT1A受体潜在拮抗剂。
Pol J Pharmacol. 1996 Jan-Feb;48(1):13-22.
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WAY100135: a novel, selective antagonist at presynaptic and postsynaptic 5-HT1A receptors.WAY100135：一种新型的、对突触前和突触后5-羟色胺1A受体具有选择性的拮抗剂。
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4
Further assessment of the antagonist properties of the novel and selective 5-HT1A receptor ligands (+)-WAY 100 135 and SDZ 216-525.新型选择性5-HT1A受体配体（+）-WAY 100 135和SDZ 216-525拮抗特性的进一步评估。
Eur J Pharmacol. 1993 Nov 2;249(1):25-35. doi: 10.1016/0014-2999(93)90658-5.
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Structure-activity relationship studies of CNS agents. Part 24: New analogs of N-tert.-butyl-3-[4-(2-methoxyphenyl)-1-piperazinyl]-2-phenylpropanamide (WAY-100135).中枢神经系统药物的构效关系研究。第24部分：N-叔丁基-3-[4-(2-甲氧基苯基)-1-哌嗪基]-2-苯基丙酰胺（WAY-100135）的新类似物
Pharmazie. 1996 Feb;51(2):72-6.
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Isoindol-1-one analogues of 4-(2'-methoxyphenyl)-1-[2'-[N-(2"-pyridyl)-p-iodobenzamido]ethyl]pipera zine (p-MPPI) as 5-HT1A receptor ligands.4-(2'-甲氧基苯基)-1-[2'-[N-(2''-吡啶基)-对碘苯甲酰胺基]乙基]哌嗪（p-MPPI）的异吲哚-1-酮类似物作为5-HT1A受体配体。
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7
The antagonist actions of WAY-100135 and its enantiomers on 5-HT1A receptor-mediated hyperpolarization of the rat isolated superior cervical ganglion.WAY-100135及其对映体对5-羟色胺1A受体介导的大鼠离体颈上神经节超极化的拮抗作用。
Naunyn Schmiedebergs Arch Pharmacol. 1993 Sep;348(3):225-7. doi: 10.1007/BF00169148.
8
S 15535: a highly selective benzodioxopiperazine 5-HT1A receptor ligand which acts as an agonist and an antagonist at presynaptic and postsynaptic sites respectively.S 15535：一种高度选择性的苯并二氧哌嗪5-HT1A受体配体，分别在突触前和突触后位点充当激动剂和拮抗剂。
Eur J Pharmacol. 1993 Jan 5;230(1):99-102. doi: 10.1016/0014-2999(93)90416-f.
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The putative 5-HT1A receptor antagonist DU125530 blocks the discriminative stimulus of the 5-HT1A receptor agonist flesinoxan in pigeons.假定的5-羟色胺1A受体拮抗剂DU125530可阻断5-羟色胺1A受体激动剂氟司立辛在鸽子身上产生的辨别刺激。
Eur J Pharmacol. 1997 May 1;325(2-3):145-53. doi: 10.1016/s0014-2999(97)00131-3.
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Novel benzodioxopiperazines acting as antagonists at postsynaptic 5-HT1A receptors and as agonists at 5-HT1A autoreceptors: a comparative pharmacological characterization with proposed 5-HT1A antagonists.新型苯并二氧哌嗪作为突触后5-HT1A受体拮抗剂和5-HT1A自身受体激动剂：与拟用的5-HT1A拮抗剂的比较药理学特征
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