Wu T T, Johnson G, Kabat E A
Department of Biochemistry, Northwestern University, Evanston, Illinois 60208.
Proteins. 1993 May;16(1):1-7. doi: 10.1002/prot.340160102.
Sequences of the third complementarity determining region of antibody heavy chains (CDRH3s) are listed according to their length. Human sequences vary from 2 to 26 amino acids residues, but less extensively in other species. When combined with the other five complementarity determining regions, this enormous length variation of CDRH3, together with amino acid substitutions in their sequences, can provide a very large number of antibody specificities and can influence the shape of antibody combining sites.
抗体重链的第三个互补决定区（CDRH3）序列按其长度列出。人类序列的长度在2至26个氨基酸残基之间变化，但在其他物种中的变化范围较小。当与其他五个互补决定区结合时，CDRH3这种巨大的长度变化，连同其序列中的氨基酸替换，能够提供大量的抗体特异性，并能影响抗体结合位点的形状。
