Wyner L M, McElroy J B, Hodge E E, Peidmonte M, Novick A C
Department of Urology, Cleveland Clinic Foundation, Ohio.
Urology. 1993 Feb;41(2):107-10. doi: 10.1016/0090-4295(93)90157-6.
From 1971-1990, 51 patients underwent renal transplantation with a kidney from a cadaver donor more than fifty-five years of age. Following transplantation, 19 kidneys (37%) functioned immediately while initial nonfunction occurred with 32 kidneys (63%). The one-year graft survival rate for kidneys with immediate function versus initial nonfunction was 84 percent and 63 percent, respectively. Graft survival was significantly impaired by increased recipient weight (p < 0.05) and by an elevated donor serum creatinine level (p < 0.05). We conclude that well-functioning kidneys from older donors can be safely and successfully used for renal transplantation. Such kidneys appear to be more susceptible to ischemic damage and should not be used when the donor serum creatinine level is elevated.
1971年至1990年期间，51例患者接受了来自年龄超过55岁的尸体供者的肾脏移植。移植后，19个肾脏（37%）立即发挥功能，而32个肾脏（63%）最初无功能。移植后立即发挥功能的肾脏与最初无功能的肾脏相比，1年移植肾存活率分别为84%和63%。受者体重增加（p<0.05）和供者血清肌酐水平升高（p<0.05）会显著损害移植肾存活。我们得出结论，来自老年供者的功能良好的肾脏可安全、成功地用于肾移植。这类肾脏似乎更容易受到缺血性损伤，当供者血清肌酐水平升高时不应使用。
