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伴有言语停顿的癫痫手术

The surgery for epilepsy with speech arrest.

作者信息

Adams C B

机构信息

Department of Neurosurgery, Radcliffe Infirmary, Oxford, U.K.

出版信息

Acta Neurochir Suppl (Wien). 1993;56:72-82. doi: 10.1007/978-3-7091-9239-9_12.

Abstract

The problems confronting patients with epilepsy, their families, and the surgeons wishing to help such patients, are discussed. It is important for physicians in other specialties to realize that epilepsy surgery is not nowadays complex, difficult, painful or uncertain; furthermore such operations are based on finding and removing focal lesions rather than "epileptogenic cortex" and the result in terms of integration of the patient into society is much improved if such intervention is performed while the patient is young, with time to gain academic and social skills after the operation. The selection of patients suitable for operation is discussed as well as methods of determining which hemisphere is dominant for speech and whether or not the focal lesion involves language centres. The majority of patients with drug resistant epilepsy suitable for operation have abnormalities in one temporal lobe. The pathological lesion is described and the advantages and disadvantages of various operations for temporal lobe epilepsy discussed. Extra-temporal cortical resection in the dominant hemisphere is also considered, particularly with reference to the preservation of language function. It is important that neurosurgeons realise that MRI and CT scanning have transformed epilepsy surgery from being a rather nebulous, time consuming art, to being for the majority of patients, a clear cut, straight forward procedure firmly based on "Oslerian" pathological principles. Far too few patients are being offered an operation (which renders 60-70% seizure free); neurosurgeons should respond to this challenge.

摘要

本文讨论了癫痫患者及其家属面临的问题,以及希望帮助此类患者的外科医生所面临的问题。其他专科的医生必须认识到,如今癫痫手术并不复杂、困难、痛苦或具有不确定性;此外,此类手术是基于找到并切除局灶性病变,而非“致痫皮层”,并且如果在患者年轻时进行这种干预,患者融入社会的效果会有很大改善,因为术后患者有时间获得学术和社交技能。本文还讨论了适合手术的患者的选择,以及确定哪个半球为语言优势半球和局灶性病变是否累及语言中枢的方法。大多数适合手术的耐药性癫痫患者在一个颞叶有异常。文中描述了病理病变,并讨论了各种颞叶癫痫手术的优缺点。还考虑了优势半球的颞外皮质切除术,特别是关于语言功能的保留。神经外科医生必须认识到,磁共振成像(MRI)和计算机断层扫描(CT)已将癫痫手术从一种相当模糊、耗时的技术,转变为对大多数患者而言,基于“奥斯勒式”病理原则的明确、直接的手术。目前接受手术(可使60% - 70%的患者无癫痫发作)的患者太少;神经外科医生应应对这一挑战。

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