Yvorra S, Desfossez L, Broin P, Disdier P, Jean-Pastor M J, Bory M
Service de cardiologie A, CHU Timone, Marseille.
Ann Cardiol Angeiol (Paris). 1993 Mar;42(3):139-41.
The authors report a case of vascular purpura occurring eleven days after the injection of streptokinase for a myocardial infarction. This adverse event falls within a context of hypersensitivity vasculitis (type III). In this particular case, imputation to the thrombolytic agent was established by the official method for the imputation of adverse or toxic effects of drugs. Routine renal function studies were normal. The outcome was satisfactory following rest only but the existence of a mixed cryoglobulinemia, responsible secondarily for cold-related distal ischemic symptomatology of the lower limbs led to the successful prescription of a short course of corticosteroids.
作者报告了1例在注射链激酶治疗心肌梗死后11天发生的血管性紫癜病例。该不良事件属于超敏性血管炎（III型）范畴。在这个特殊病例中，通过药物不良反应或毒性归因的官方方法确定了与溶栓剂的关联。常规肾功能检查正常。仅通过休息，结果就令人满意，但存在混合性冷球蛋白血症，继而导致下肢与寒冷相关的远端缺血症状，这使得成功开具了一个短期的皮质类固醇疗程。
