Sinisi A A, Di Finizio B, Lettieri F, Pasquali D, Scurini C, De Bellis A, Bellastella A
Cattedra di Endocrinologia, I Facoltà di Medicina e Chirurgia, Università di Napoli, Italy.
Arch Androl. 1993 May-Jun;30(3):147-52. doi: 10.3109/01485019308987748.
Testicular torsion, one of the most common pediatric urological emergencies, is rarely familial. This study deals with the sixth recorded family with familial testicular torsion and the effects on the spermatogenesis and the appearance of testicular autoantibodies in three affected subjects (two brothers, aged 18 and 15 years, and their father, aged 48 years). The father and one of the brothers, who had peripubertal unilateral testicular torsion, presented normal fertility and oligozoospermia, respectively. The other brother, who had a history of bilateral testicular torsion, did not present pubertal development until he was 18 years old and he needed substitutive testosterone therapy. Sperm autoantibody titer increased only in the two cases with unilateral torsion and remained unmodified at a 5-year follow-up. The results indicate that testicular torsion can cause variable degrees of spermatogenesis impairment and induce development of autoantibodies against spermatozoa and gonadal antigens. The persistence of fertility in the father and the progressive spermatogenesis recovery in one of the affected sons suggest that the damaging effects of these autoantibodies deserve further investigation.
睾丸扭转是最常见的小儿泌尿外科急症之一，很少具有家族性。本研究涉及第六个有家族性睾丸扭转的记录家族，以及对三名受影响个体（两名兄弟，分别为18岁和15岁，以及他们48岁的父亲）精子发生和睾丸自身抗体出现情况的影响。父亲和其中一名在青春期前后发生单侧睾丸扭转的兄弟，分别表现为生育力正常和少精子症。另一名有双侧睾丸扭转病史的兄弟，直到18岁才出现青春期发育，需要替代睾酮治疗。仅在两例单侧扭转病例中精子自身抗体滴度升高，且在5年随访中保持不变。结果表明，睾丸扭转可导致不同程度的精子发生损害，并诱导针对精子和性腺抗原的自身抗体产生。父亲生育力的持续存在以及其中一名受影响儿子精子发生的逐渐恢复表明，这些自身抗体的破坏作用值得进一步研究。
