[Synthesis of lipophilic and fluorescent derivatives of N-acetylmuramoyl-L-alanyl-D-isoglutamine].

Synthesis of lipophilic derivatives of N-acetylmuramyl-L-alanyl-D-isoglutamine (MDP) by condensation of the C-terminal amino acid moiety in MDP molecule with phosphatidylethanolamine was carried out. Fluorescent lipophilic derivatives of MDP were synthesized by condensation of MDP with phosphatidylethanolamines labelled in the hydrophobic moiety, e.g. 1-acyl-2-[9(10)-(4-pyrenyl)stearoyl]-sn-glycero-3-phosphoethanolamine and pyrenylphosphatidylethanolamine.