核苷。CVI。1 - N - 甲基 - 5 -（β - D - 呋喃核糖基）尿嘧啶（1 - N - 甲基 - φ - 尿苷）的合成及其与克拉伦斯链霉菌变种所产生的一种代谢物的同一性。
Nucleosides. CVI. Syntheses of 1-N-methyl-5-(beta-D-ribofuranosyl)uracil (1-N-methyl-phi-uridine) and its identity with a metabolite elaborated by Streptomyces platensis var. clarensis.
作者信息
Reichman U, Hirota K, Chu C K, Watanbe K A, Fox J J
出版信息
J Antibiot (Tokyo). 1977 Feb;30(2):129-31. doi: 10.7164/antibiotics.30.129.
PMID:849915
Abstract
Very recently, 1-N-methyl-psi-uridine was isolated from the culture filtrate of Streptomyces platensis var. clarensis along with an antibacterial and antiviral antibiotic, U-44590. We achieved chemical syntheses of 1-N-methyl-psi-uridine by selective methylation of psi-uridine in two different routes and established the identity of the synthetic nucleoside with the natural product.
摘要
最近，1-N-甲基-假尿苷与一种抗菌抗病毒抗生素U-44590一起从克拉伦西斯链霉菌的培养滤液中分离出来。我们通过两种不同的途径对假尿苷进行选择性甲基化，实现了1-N-甲基-假尿苷的化学合成，并确定了合成核苷与天然产物的一致性。
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