Ewing's sarcoma -- functional effects of radiation therapy.

Long-term morbidity was assessed in fifty-five patients with Ewing's sarcoma who survived two years or longer. Primary site, radiation dosage, and age of the patient all had an important bearing on the end result. Guidelines for treatment of the primary tumor were developed. Patients with upper-extremity lesions were generally best treated by radiotherapy. Young children and some of the older patients with lesions in the lower extremity were generally best treated by primary amputation, depending on the site of the lesion.