成年人类的犁鼻上皮细胞表达神经元特异性分子。

Vomeronasal epithelial cells of the adult human express neuron-specific molecules.

作者信息

Takami S, Getchell M L, Chen Y, Monti-Bloch L, Berliner D L, Stensaas L J, Getchell T V

机构信息

Department of Physiology and Biophysics, University of Kentucky College of Medicine, Lexington 40536.

出版信息

Neuroreport. 1993 Apr;4(4):375-8. doi: 10.1097/00001756-199304000-00008.

DOI:10.1097/00001756-199304000-00008

PMID:8499591

Abstract

Immunohistochemical localization of three molecular markers, neuron-specific enolase (NSE) and protein gene product (PGP) 9.5 for neurons and neuroendocrine cells, and olfactory marker protein (OMP) for olfactory receptor neurons (ORNs) was investigated in the vomeronasal epithelium (VNE) of adult humans. NSE- and PGP 9.5-immunoreactive cells were identified in the VNE. ORNs in the olfactory epithelium of approximately age-matched controls were immunoreactive for the three markers. Most NSE-immunoreactive cells in the VNE were bipolar and similar in shape to the NSE- and PGP 9.5-immunoreactive ORNs. The results indicate that the adult human VNE contains cells expressing two molecular markers characteristic of neurons and that these cells bear a striking morphological similarity to ORNs.

摘要

研究了三种分子标记物在成年人类犁鼻器上皮（VNE）中的免疫组织化学定位，这三种分子标记物分别是：用于神经元和神经内分泌细胞的神经元特异性烯醇化酶（NSE）和蛋白基因产物（PGP）9.5，以及用于嗅觉受体神经元（ORN）的嗅觉标记蛋白（OMP）。在VNE中鉴定出了NSE和PGP 9.5免疫反应性细胞。在年龄大致匹配的对照组的嗅觉上皮中的ORN对这三种标记物均有免疫反应。VNE中大多数NSE免疫反应性细胞是双极的，并且在形态上与NSE和PGP 9.5免疫反应性ORN相似。结果表明，成年人类VNE含有表达两种神经元特征性分子标记物的细胞，并且这些细胞在形态上与ORN具有显著相似性。