Schuster A, Wahn V
Universitäts-Kinderklinik, Düsseldorf, BRD.
Infusionsther Transfusionsmed. 1993 Apr;20 Suppl 1:141-4; discussion 145.
Treatment of severe bronchial asthma usually requires the use of steroids. Given the known side effects of steroid treatment, potential alternative therapeutical strategies are currently evaluated; among others, intravenously administered immunoglobulins (ivIg) may be considered. In one study of 5 children with bronchial asthma and IgG subclass deficiency, an improvement of asthma was demonstrated in 4 out of the 5 patients under ivIg treatment over several months. In another study on ivIg treatment in 8 immunocompetent children with steroid-dependent asthma, there also was an improvement of asthma, leading to a reduction in the required steroid dose; furthermore, there was a diminution in skin prick test reactivity. At present, only speculations can be made about the possible mechanisms of action.
重度支气管哮喘的治疗通常需要使用类固醇。鉴于类固醇治疗已知的副作用，目前正在评估潜在的替代治疗策略；其中，静脉注射免疫球蛋白（ivIg）可能是一种选择。在一项针对5名患有支气管哮喘和IgG亚类缺乏症儿童的研究中，5名接受ivIg治疗数月的患者中有4名哮喘症状得到改善。在另一项针对8名免疫功能正常的类固醇依赖型哮喘儿童进行的ivIg治疗研究中，哮喘症状也有所改善，导致所需类固醇剂量减少；此外，皮肤点刺试验反应性降低。目前，对于其可能的作用机制只能进行推测。
