Körholz D, Grünewald S, Burdach S, Göbel U
Klinik für pädiatrische Hämatologie und Onkologie, Heinrich-Heine-Universität, Düsseldorf, BRD.
Infusionsther Transfusionsmed. 1993 Apr;20 Suppl 1:68-71; discussion 72.
Following bone marrow transplantation many patients are suffering from an impaired immunoglobulin production. Treatment with intravenous immunoglobulin has significantly reduced the incidence of infections as well as severe graft-versus-host disease during the early posttransplant period. However, no complete protection of the patients has been achieved. According to our own observations, especially patients with a decreased production of IgM antibodies seem to have an increased risk of cytomegalovirus-induced pneumonitis. During the late posttransplant period, patients with IgG subclass deficiency are at risk of acquiring gram-positive infections. However, randomized studies investigating the effect of immunoglobulin treatment during the late posttransplant phase have not yet been conducted.
骨髓移植后，许多患者存在免疫球蛋白产生受损的情况。在移植后的早期阶段，静脉注射免疫球蛋白治疗显著降低了感染以及严重移植物抗宿主病的发生率。然而，尚未实现对患者的完全保护。根据我们自己的观察，尤其是IgM抗体产生减少的患者，似乎患巨细胞病毒诱导的肺炎的风险增加。在移植后的后期阶段，IgG亚类缺乏的患者有获得革兰氏阳性菌感染的风险。然而，尚未进行调查移植后期免疫球蛋白治疗效果的随机研究。
