嗜热古细菌嗜热栖热放线菌中修饰叶酸的结构。
Structures of the modified folates in the extremely thermophilic archaebacterium Thermococcus litoralis.
作者信息
White R H
机构信息
Department of Biochemistry and Nutrition, Virginia Polytechnic Institute and State University, Blacksburg 24061-0308.
出版信息
J Bacteriol. 1993 Jun;175(11):3661-3. doi: 10.1128/jb.175.11.3661-3663.1993.
Abstract
The chemical structures of the two modified folates present in Thermococcus litoralis were established. These compounds, each containing a core structure of 1-[4-[[1-(2-amino-7-methyl- 4-oxo-6-pteridinyl)-ethyl]amino]phenyl]-1-deoxy-[1-alpha-D- ribofuranosyl]-ribitol, were characterized. The five position of the ribose in this core structure was beta-linked to the C-1 of a poly-beta (1-->4)N-acetylglucosamine having a chain length of four or five N-acetylglucosamine residues. Thus, these compounds are N-acetylglucosamine homologs of the modified folates found in Pyrococcus furiosus.
摘要
确定了嗜热栖热菌中存在的两种修饰叶酸的化学结构。对这些化合物进行了表征，它们各自含有1-[4-[[1-(2-氨基-7-甲基-4-氧代-6-蝶啶基)-乙基]氨基]苯基]-1-脱氧-[1-α-D-呋喃核糖基]-核糖醇的核心结构。该核心结构中核糖的5位与具有四或五个N-乙酰葡糖胺残基链长的聚-β(1→4)N-乙酰葡糖胺的C-1位以β-连接。因此，这些化合物是在激烈火球菌中发现的修饰叶酸的N-乙酰葡糖胺同系物。
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本文引用的文献
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