Cicero T J, Bell R D, Meyer E R, Schweitzer J
J Pharmacol Exp Ther. 1977 Apr;201(1):76-83.
The effects of narcotics on several aspects of the hypothalamic-pituitary-gonadal axis were examined in the male rat. Our results indicate that a large number of narcotics acutely depress serum luteinizing hormone levels and that these reduced gonadotropin levels lead to a subsequent fall (1-2 hours later) in serum testosterone levels. The luteinizing hormone-depleting effect of the narcotics appears to represent a specific narcotic action since the (-)-isomers of the narcotics were much more effective than the ()-isomers, naloxone antagonized their effects and tolerance rapidly developed. Further, our studies indicate that the impairment of the functional and structural integrity of the secondary sex organs produced by chronic narcotic administration is not due to a direct effect of these drugs since they have no effect on the uptake of subcellular distribution of testosterone in the secondary sex organs or on the androgen-dependent accumulation of myo-inositol. Consequently, it appears that the testosterone depletion produced by the narcotics is solely responsible for their adverse effect on the secondary sex organs. The results of these studies suggest that the effects of the narcotics on the hypothalamic-pituitary-gonadal axis are confined to either the hypthalamus or the pituitary gland.
在雄性大鼠中研究了麻醉品对下丘脑 - 垂体 - 性腺轴几个方面的影响。我们的结果表明，大量麻醉品会急性降低血清促黄体生成素水平，而这些降低的促性腺激素水平会导致血清睾酮水平随后下降（1 - 2小时后）。麻醉品的促黄体生成素消耗作用似乎代表一种特定的麻醉品作用，因为麻醉品的（-） - 异构体比（+） - 异构体更有效，纳洛酮可拮抗其作用且耐受性迅速产生。此外，我们的研究表明，长期给予麻醉品导致的次级性器官功能和结构完整性受损并非由于这些药物的直接作用，因为它们对次级性器官中睾酮的亚细胞分布摄取或对肌醇的雄激素依赖性积累没有影响。因此，似乎麻醉品导致的睾酮耗竭是其对次级性器官产生不良影响的唯一原因。这些研究结果表明，麻醉品对下丘脑 - 垂体 - 性腺轴的影响局限于下丘脑或垂体。
