Fry L L, Yee R W
J Cataract Refract Surg. 1993 May;19(3):409-12. doi: 10.1016/s0886-3350(13)80315-x.
A randomized masked study was performed to compare Healon GV, a new higher molecular weight sodium hyaluronate viscoelastic, with Healon in extracapsular cataract surgery with posterior chamber intraocular lens insertion. Seventy patients were randomly divided into two groups. Postoperative intraocular pressures, pachymetry, endothelial cell counts and morphology, amount of viscoelastic and irrigating solution used, difficulty of surgery, and postoperative flare and cells were measured. Postoperative pressures were not significantly different between the Healon and Healon GV treatment groups, except at the eight-hour observation period, when the pressure was higher in the Healon GV group (P = .02). There was a significant (P = .002) reduction in the amount of viscoelastic required in the Healon GV group. Cell counts and morphology were not significantly different between the groups. Other parameters showed no significant difference. Clinically, Healon GV handled like Healon during instillation into the anterior chamber and aspiration at the end of the case. It did, however, appear to be much more effective at maintaining the anterior chamber, as demonstrated in the smaller amount of viscoelastic required.
进行了一项随机双盲研究，以比较新型高分子量透明质酸钠粘弹剂Healon GV与Healon在白内障囊外摘除联合后房型人工晶状体植入手术中的效果。70例患者被随机分为两组。测量了术后眼压、角膜厚度、内皮细胞计数及形态、所用粘弹剂和冲洗液的量、手术难度以及术后房水闪光和细胞情况。Healon组和Healon GV治疗组术后眼压无显著差异，但在8小时观察期时，Healon GV组眼压较高（P = 0.02）。Healon GV组所需粘弹剂的量显著减少（P = 0.002）。两组间细胞计数和形态无显著差异。其他参数也无显著差异。临床上，Healon GV在前房注入和手术结束时抽吸过程中与Healon操作相似。然而，如所需粘弹剂用量较少所示，它在维持前房方面似乎更有效。
