Stastny P, Fernandez-Viña M, Cerna M, Havelka S, Ivaskova E, Vavrincova P
Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas 75235.
J Rheumatol Suppl. 1993 Apr;37:5-8.
Adult rheumatoid factor (RF) positive rheumatoid arthritis (RA) and RF positive arthritis of childhood are associated with DRB10401 in Caucasians, and DRB10405 in Orientals, and in Ashkenazi and nonAshkenazi Jews. Certain other DRB1 alleles (DRB1*0101,1001) which have a similar sequence in the 3rd hypervariable region of the 1st domain are also associated with RA, but they appear to function as weaker risk factors. The difference in the relative strength of the associations is likely to be due to structural differences in the 1st and 2nd variable regions of the first domain of these alleles. Similarities and differences in the HLA associations between North American Caucasoid patients with juvenile arthritis in Dallas, TX, USA, and in Prague, Czechoslovakia, are discussed.
在白种人、东方人、德系犹太人和非德系犹太人中，成人类风湿因子（RF）阳性的类风湿关节炎（RA）以及儿童RF阳性关节炎与DRB10401相关，在东方人以及德系犹太人和非德系犹太人中则与DRB10405相关。某些在第一结构域的第3高变区具有相似序列的其他DRB1等位基因（DRB1*0101、1001）也与RA相关，但它们似乎是较弱的风险因素。关联相对强度的差异可能是由于这些等位基因第一结构域的第一和第二可变区的结构差异所致。本文讨论了美国得克萨斯州达拉斯市和捷克斯洛伐克布拉格市的北美白种人青少年关节炎患者之间HLA关联的异同。
