Hamann K U
Klin Monbl Augenheilkd. 1977 Jan;170(1):89-94.
The author presents a case of exogenous, retrocorneal, limbal infiltration due to chromomycosis, following cataractextraction. Since the etiology of this keratitis was not recognized at the beginning, steroids were applied causing an exacerbation of the keratitis with hypopyoniritis. A perforating, excentric keratoplasty was performed, yielding material for the histological diagnosis, and for the identification of the responsible agent. The cultural and morphological properties were typical of those of a dematiaceous fungus, a chromomycosis. In vitro studies demonstrated this fungus to be less sensitive to 5-fluorcytosin and clotrimazole, and to be less resistant to natamycin, mystatin and amphotericin-B, paving the road for an effective conservative therapy following surgery.
作者报告了1例白内障摘除术后因着色芽生菌病导致的外源性角膜后弹力层角膜缘浸润病例。由于一开始未认识到这种角膜炎的病因，应用了类固醇，导致角膜炎伴前房积脓性虹膜睫状体炎加重。进行了偏心性穿透性角膜移植术，获得了用于组织学诊断和鉴定病原体的材料。培养和形态学特征典型地符合暗色真菌（即着色芽生菌病）的特征。体外研究表明，这种真菌对5-氟胞嘧啶和克霉唑不太敏感，而对那他霉素、制霉菌素和两性霉素B的耐药性较低，为术后有效的保守治疗铺平了道路。
