寻常型银屑病患者及其家族中 HLA 抗原之间的关联
Association between HLA antigens and families with psoriasis vulgaris.
作者信息
Cao K, Song F J, Li H G, Xu S Y, Liu Z H, Su X H, Wang F X
机构信息
Dermatology Department, First Hospital, China Medical University, Shenyang.
出版信息
Chin Med J (Engl). 1993 Feb;106(2):132-5.
This paper typed HLA-A, B, C and DR antigens in patients with psoriasis vulgaris and healthy persons in 12 families. The phenotype frequencies of HLA-A1, B13, B17, Cw4 and Cw6 in the patients were higher than those in the controls. The analysis of haplotype segregation showed that HLA haplotypes in families with more psoriatic cases were marked deviation from random distribution. One or two HLA haplotypes sharing among affected siblings occurred more frequently than expected. The result of Lods score for six families showed that there was a close linkage between the gene of psoriasis vulgaris and HLA antigens. The gene of psoriasis was coincided with the recessive hereditary mode.
本文对12个家庭中的寻常型银屑病患者和健康人进行了HLA - A、B、C和DR抗原分型。患者中HLA - A1、B13、B17、Cw4和Cw6的表型频率高于对照组。单倍型分离分析表明，银屑病病例较多的家庭中HLA单倍型明显偏离随机分布。受累同胞间共享一个或两个HLA单倍型的情况比预期更频繁。对6个家庭的连锁分析结果显示，寻常型银屑病基因与HLA抗原之间存在紧密连锁。银屑病基因符合隐性遗传模式。
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