Notario A, Ricetti M, Comin U, Cardenà A, Grandi E, Bernini P
Minerva Med. 1977 Mar 24;68(14):903-16.
A study of membrane proteins in pernicious anaemia and other haemolitic and anhaemolytic erythropathies is reported. Cellulose acetate and acrylamide gel electrophoresis was carried out and acid, neutral and basic amino acid contents were determined. Relatively specific alterations were noted. Chromatographic analysis of the amino acids suggested that in pernicious anaemia, as in other conditions, structural changes take place in the red cell membrane, though these may be confined to certain sectors. A constant alteration related to the concomitance or otherwise of erythrocyte hyperhaemolysis, however, could not be discerned.
本文报道了一项关于恶性贫血以及其他溶血性和非溶血性红细胞病中膜蛋白的研究。进行了醋酸纤维素和丙烯酰胺凝胶电泳，并测定了酸性、中性和碱性氨基酸含量。发现了相对特异性的改变。氨基酸的色谱分析表明，与其他病症一样，在恶性贫血中红细胞膜会发生结构变化，尽管这些变化可能局限于某些部分。然而，未能发现与红细胞过度溶血的伴随情况相关的持续改变。
