Yamada T, Yamada M, Sasamoto K, Nakamura H, Mishima T, Yasueda H, Shida T, Iikura Y
Department of Pediatrics, Jikei University School of Medicine.
Arerugi. 1993 Feb;42(2):136-41.
Hen's egg white lysozyme (HEL) is one of the minor allergen in hen's egg white. HEL is commonly used to treat disease of respiratory tract, because it have the effect to dissolve mucopolysaccharide and anti-inflammatory action. We examined specific IgE antibody titers (IgE-HEL) in patients with egg allergy and allergic patients to other antigen than egg. Results indicated that 16.37 +/- 29.56 (PRU/ml) (mean +/- SD) of IgE-HEL was found in 30 out of the 39 allergic patients to egg, and 23 (66.7%) out of the 39 patients studied showed RAST scores of more than 2. On the other hand, 1.08 +/- 0.92 (PRU/ml) of IgE-HEL in 12 out of the 44 allergic patients to other antigen than egg, and 5 (11.4%) out of the 44 patients studied showed RAST scores of more than 2. Moreover, we treated a patient who developed anaphylaxis after taking HEL. 1.0 (PRU/ml) of HEL-IgE was found in this patient. These results suggest that we should be careful in treating allergic patients with HEL.
鸡蛋清溶菌酶（HEL）是鸡蛋清中的次要过敏原之一。HEL常用于治疗呼吸道疾病，因为它具有溶解黏多糖的作用和抗炎作用。我们检测了鸡蛋过敏患者以及对除鸡蛋以外其他抗原过敏的患者体内的特异性IgE抗体滴度（IgE-HEL）。结果显示，39例鸡蛋过敏患者中有30例的IgE-HEL为16.37±29.56（PRU/ml）（均值±标准差），且在39例研究患者中有23例（66.7%）的放射性变应原吸附试验（RAST）评分大于2。另一方面，44例对除鸡蛋以外其他抗原过敏的患者中有12例的IgE-HEL为1.08±0.92（PRU/ml），且在44例研究患者中有5例（11.4%）的RAST评分大于2。此外，我们治疗了一名服用HEL后发生过敏反应的患者。该患者体内的HEL-IgE为1.0（PRU/ml）。这些结果表明，我们在使用HEL治疗过敏患者时应谨慎。
