血管紧张素AT1受体在大鼠心脏传导系统中的定位
Localization of angiotensin AT1 receptors in the rat heart conduction system.
作者信息
Saavedra J M, Viswanathan M, Shigematsu K
机构信息
Section on Pharmacology, NIMH, Bethesda, MD 20892.
出版信息
Eur J Pharmacol. 1993 Apr 28;235(2-3):301-3. doi: 10.1016/0014-2999(93)90150-g.
We characterized angiotensin II receptor subtypes in the conduction system of the rat heart using quantitative autoradiography. In both the sinoatrial and atrioventricular nodes, binding could be totally displaced by losartan, and was insensitive to PD 123177, indicating that angiotensin II receptors in the conduction system of the rat heart belong to the AT1 subtype. Angiotensin AT1 receptors could play a direct role in the regulation of the heart chronotropic properties.
我们使用定量放射自显影技术对大鼠心脏传导系统中的血管紧张素II受体亚型进行了表征。在窦房结和房室结中，结合均可被氯沙坦完全取代，且对PD 123177不敏感，这表明大鼠心脏传导系统中的血管紧张素II受体属于AT1亚型。血管紧张素AT1受体可能在心脏变时性特性的调节中发挥直接作用。
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