Khaitov R M, Galperin E I, Podobin N P, Leskov V P, Fedenko E S, Prosorovsky N S, Akhaladze G G, Prokopenko V P
Institute of Immunology, Russian Ministry of Public Health, Moscow.
Hepatogastroenterology. 1993 Apr;40(2):126-30.
An immunological examination of patients with septic cholangitis revealed secondary immunodeficiency. Traditional methods of therapy and immunocorrection were ineffective in eight patients with septic cholangitis. They were treated with extracorporeal immunopharmacotherapy using diuciphon. For the accomplishing detoxication, this was used in combination with plasma exchange. The course of treatment consisted of 3 or 4 procedures, within a 3- or 4-day interval. As a result of extracorporeal immunocorrection, patients were observed to have positive immunological indexes, demonstrated by the normalization of the lymphocyte count in 5 of 6 patients, CD3+ and CD4+ in 3 patients, and CD8+ in 4. Four patients had clinical remissions (0.5 year), and 3 patients underwent surgery with no septic postoperative complications.
对化脓性胆管炎患者的免疫学检查显示存在继发性免疫缺陷。传统治疗方法和免疫纠正措施对8例化脓性胆管炎患者无效。他们采用了使用二西芬的体外免疫药物治疗。为实现解毒，将其与血浆置换联合使用。治疗疗程包括3或4次治疗，间隔3或4天。体外免疫纠正的结果是，患者的免疫学指标呈阳性，6例患者中有5例淋巴细胞计数恢复正常，3例患者CD3 +和CD4 +恢复正常，4例患者CD8 +恢复正常。4例患者实现临床缓解（0.5年），3例患者接受手术，术后无败血症并发症。
