Morimoto S, Yamada K, Hiramitsu S, Uemura A, Kubo N, Kimura K, Yamaguchi T, Watanabe S, Mizuno Y
Department of Internal Medicine, Fujita Health University School of Medicine, Aichi Prefecture, Japan.
Jpn Circ J. 1993 May;57(5):388-94. doi: 10.1253/jcj.57.388.
We investigated smooth muscle cell proliferation associated with restenosis after percutaneous transluminal coronary angioplasty (PTCA) in 8 arteries with fragmented internal elastic lamina obtained at autopsy in 7 patients who died between 2 months to 2 years 11 months after coronary angioplasty. The internal elastic lamina fragmentation, measured longitudinally along the blood vessels, measured 6.6 +/- 6.9 mm. Smooth muscle cell proliferation was concentrated around the fragmented internal elastic lamina, extending longitudinally even to unfragmented areas. The proliferation of smooth muscle cells extended for 1.8 +/- 2.2 mm in the proximal portion of the fragmentation, and for 2.0 +/- 2.9 mm in the distal portion. The possibility of new stenoses resulting from smooth muscle cell proliferation at sites adjacent to those subjected to PTCA should be borne in mind when PTCA of the proximal segments of the left anterior descending coronary artery is contemplated.
我们对7例在冠状动脉血管成形术后2个月至2年11个月死亡的患者尸检获取的8条内弹性膜破碎的动脉进行研究，以探讨经皮腔内冠状动脉血管成形术（PTCA）后再狭窄相关的平滑肌细胞增殖情况。沿血管纵向测量，内弹性膜破碎长度为6.6±6.9毫米。平滑肌细胞增殖集中在内弹性膜破碎部位周围，甚至纵向延伸至未破碎区域。平滑肌细胞增殖在破碎近端延伸1.8±2.2毫米，在远端延伸2.0±2.9毫米。当考虑对左前降支近端进行PTCA时，应牢记在PTCA部位相邻处因平滑肌细胞增殖导致新狭窄的可能性。
