Sutinen S, Sutinen S, Huhti E
Am J Clin Pathol. 1977 Apr;67(4):328-33. doi: 10.1093/ajcp/67.4.328.
Ultrastructural studies of an open lung biopsy of a patient who had lymphoid interstitial pneumonia, Sjögren's syndrome, and a highly elevated level of immunoglobulin M in the serum disclosed the presence in bronchiolar epithelium of numerous round electron-dense particles 70-120 nm in diameter. These were closely reminiscent of the oncogenic type-A viral particles associated with tumors of laboratory and wild mice. In the inflammatory infiltrate the morphology of some small lymphocytes was suggestive of germinative activity, although no germinal centers were found. Plasma cells, which were numerous in the vicinity of the bronchiolar epithelium, contained varying amounts of electron-dense material, probably immunoglobulin, which was also deposited in the irregulary thickened epithelial basal lamina. The observations support the theory that viral infection may be the stimulus to the immunologic abnormalities observed in patients with lymphoid interstitial pneumonia and Sjögren's syndrome.
对一名患有淋巴样间质性肺炎、干燥综合征且血清免疫球蛋白M水平显著升高的患者进行的开放性肺活检超微结构研究显示，在细支气管上皮中存在大量直径为70 - 120纳米的圆形电子致密颗粒。这些颗粒与实验室和野生小鼠肿瘤相关的致癌性A型病毒颗粒极为相似。在炎性浸润中，一些小淋巴细胞的形态提示有生发活性，尽管未发现生发中心。在细支气管上皮附近大量存在的浆细胞含有不同数量的电子致密物质，可能是免疫球蛋白，这些物质也沉积在不规则增厚的上皮基底膜中。这些观察结果支持了病毒感染可能是淋巴样间质性肺炎和干燥综合征患者所观察到的免疫异常的刺激因素这一理论。
