Antonini A, Stryker M P
W. M. Keck Foundation Center for Integrative Neuroscience, Department of Physiology, University of California, San Francisco 94143.
Science. 1993 Jun 18;260(5115):1819-21. doi: 10.1126/science.8511592.
If vision in one eye is blurred or occluded during a critical period in postnatal development, neurons in the visual cortex lose their responses to stimulation through that eye within a few days. Anatomical changes in the nerve terminals that provide input to the visual cortex have previously been observed only after weeks of deprivation, suggesting that synapses become physiologically ineffective before the branches on which they sit are withdrawn. Reconstruction of single geniculocortical axonal arbors in the cat after either brief or prolonged monocular occlusion revealed striking axonal rearrangements in both instances. Rapid withdrawal of the branches of deprived-eye arbors suggests that axonal branches bearing synapses respond quickly to changing patterns of neuronal activity.
如果在出生后发育的关键时期，一只眼睛的视力出现模糊或被遮挡，视觉皮层中的神经元会在几天内失去对通过该眼睛传来刺激的反应。以前，只有在剥夺数周后才观察到向视觉皮层提供输入的神经末梢的解剖学变化，这表明突触在其所在分支撤回之前就已在生理上失效。对猫在短暂或长期单眼遮挡后单个膝状体皮质轴突分支的重建显示，在这两种情况下都有明显的轴突重排。剥夺眼分支的快速撤回表明，带有突触的轴突分支对神经元活动模式的变化反应迅速。
